2 edition of Liposomal hydrogel surface coatings for localized delivery of therapeutic compounds. found in the catalog.
Liposomal hydrogel surface coatings for localized delivery of therapeutic compounds.
Valerio Di Tizio
Written in English
|The Physical Object|
3 1. Introduction38 39 A major aim in the development of modern hydrogel formulations such as those currently 40 used in wound dressings, is to achieve the effective and accurate delivery of the required 41 therapeutic . ABSTRACT: The design of liposomal delivery systems for hydrophobic drug molecules release of such compounds has been slow. This report describes an efﬂux transport liposomes with a rigid gel Cited by:
The development of stealth liposomes is underway by utilizing the surface coating of a hydrophilic polymer, usually a lipid derivative of polyethylene glycol (PEG), to extend the circulation Cited by: Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. Current approaches for topical delivery of liposomes Cited by:
Abstract. Liposomes are used as carriers to deliver the entrapped drugs into the skin, beneath the skin or into the systemic circulation, but the major limitation of using liposomes topically onto the skin is Cited by: 3. Title:Liposomal Hydrogels: A Novel Drug Delivery System for Wound Dressing VOLUME: 7 ISSUE: 3 Author(s):Shailesh Thirumaleshwar, Parthasarthi K. Kulkarni and Devegowda V. Gowda Affiliation:Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore , Karnataka, India. Keywords:Liposomal hydrogel Cited by: 7.
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LIPOSOMAL HYDROGEL SURFACE COATINGS FOR LOCALIZED DELIVERY OF TEERAPEUTIC COMPOUNDS Degree of Doctor of Philosophy, 1 Valerio DiTizio Graduate Department o motany and Institute of Biornaterials and Biomedical Engineering University of Toronto ABSTRACT A novel coating combining the delayed release properties of antibiotic-loaded liposomes Cited by: 1.
Liposomes have been utilized as a drug delivery carrier for a wide range of therapeutic compounds and diagnostic agents, such as drug molecules, gene therapy and bioactive agents Cited by: To facilitate the translation of this platform for clinical tests and uses, herein we integrate nanoparticle-stabilized liposomes with hydrogel technology for more effective and sustained topical drug delivery.
The hydrogel formulation not only preserves the structural integrity of the nanoparticle-stabilized liposomes, but also allows for controllable viscoeleasticity and tunable liposome release by: Figure 1.
Schematic illustration of hydrogel containing nanoparticle-stabilized liposomes for topical antimicrobial delivery.
Carboxyl-modiﬁed gold nanoparticles (AuC) were adsorbed onto the outer surfaces of cationic liposomes to stabilize them against fusion. The AuC liposomes were subsequently embedded into an acrylamide-based hydrogel.
compound in a time regulated and locally restricted manner to the target site. New approaches to construct improved liposomes for therapeutic delivery have addressed, on one end, biophysical.
Until approximately a decade ago, most liposomal drug delivery applications were hampered by short blood lifetimes of conventional lipid vesicles and their preferential accumulation in organs of the reticuloendothelial (RES) system. 1,2 In an effort to address these problems, various liposomal surface modifiers were tested, including dicarboxylic acids, synthetic and natural polymers, and oligocaccharides.
a surface coating of a hydrophilic carbohydrate or polymer, liposomal drug delivery str ucture for the lung is.
Application of liposomes in medicine and drug delivery. Abstract. This chapter expands upon some of the basic concepts regarding drug delivery and takes a tour through various regions of the body that are commonly treated locally with controlled.
There are three commercial liposome formulations of anthracyclines all with different formulations: Myocet ® liposomes which are relatively large in size (∼ nm) and are composed of egg phosphatidylcholine and cholesterol, and therefore do not have a modified hydrophilic surface coating.
Owing to their larger size and surface. In one study, cellular intake increased 9-fold as the liposome size was decreased from nm to 97 nm, and cellular intake was increased fold at 64 nm.
3 In addition, the therapeutic capabilities of a liposomal delivery system are also related to how fast the body clears the liposomes. Liposomal hydrogel formulation for transdermal delivery of pirfenidone Article (PDF Available) in Journal of Liposome Research 26(2) June with Reads How we measure 'reads'.
It can also reduce liposome surface tension and further enhance liposome stability. 15,16 Intriguingly, the charge and charge density of both the nanoparticle stabilizers and the liposomes can be precisely tailored to enable stimulus-responsive binding and detaching of the nanoparticles, thereby allowing for an on-demand control over liposome fusion activity for smart drug by: The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas.
They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo.
This enables effective delivery of encapsulated compounds Cited by: Abstract. Natural polyphenols, such as resveratrol (RES) or epicatechin (EPI), are attractive for treatments of various diseases, including vaginal infections and inflammation, because of their strong anti-oxidative and anti-inflammatory properties.
However, their low solubility and consequent poor bioavailability limit Cited by: 6. Research Article DEVELOPMENT AND CHARACTERIZATION OF TOPICAL LIPOSOMAL GEL FORMULATION FOR ANTI-CELLULITE ACTIVITY LALIT K VYAS1, KIRAN K TAPAR2, RAJESH K File Size: KB.
Liposomes as carriers for poorly soluble drugs/active molecules assist in overcoming this hydrogel limitation; the combination of these two delivery systems is a promising approach to achieve controlled dermal drug delivery and effective localized skin therapy [18,19,20].
The liposomal phospholipid bilayers allow the incorporation of lipophilic substances, improving their solubilization and enabling their inclusion into the hydrophilic chitosan : Selenia Ternullo, Laura Victoria Schulte Werning, Ann Mari Holsæter, Nataša Škalko-Basnet.
Biodegradable liposome-encapsulated hydrogels for biomedical applications: a marriage of convenience. Santiago Grijalvo ab, Judith Mayr c, Ramon Eritja ab and David Díaz Díaz * ac a Cited by: ABSTRACT. Aim: The aims of this study were to develop liposome enriched Dexibuprofen liposomal hydrogels for topical delivery, perform in vitro release studies and in vivo permeation studies through mice/rat skin, and evaluate the efficacy of liposomal gels against inflammation induced purpose was to provide the delivery.
The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds Cited by: Colon targeted drug delivery is an active area of research for diseases affecting the colon, as it shows promise in improving the efficacy of therapeutics and reducing systemic toxicity.
Improved oral drug delivery design has unequivocally improved the bioavailability of drugs to the colon. The oral route of administration is the most common method of drug by:.
Liposomes can be coated with a functionalized polymer, creating a nanobin, to improve targeted drug delivery. 93 Long-circulating liposomes (or “stealth liposomes”) can be obtained by coating with polyethylenglycol chains (PEGylated liposomes). 94 The most important application of liposomal delivery is AmBisome®, an injectable liposomal formulation of amphotericin B that consists of the drug dissolved in the lipid bilayer of unilamellar liposomes .liposome has been used as a carrier to deliver a wide variety of compounds in its aqueous compartment.
They can encapsulate and effectively deliver both hydrophilic and lipophilic substances,[2, 3]and may be used as a non-toxic vehicle for insoluble drugs. Liposome. Preparation Of Liposomal Gel: 28 Gel was prepared using carbopol® NF (1, and 2%). The appropriate quantity of carbopol powder was dispersed into distilled water under .